Article
Increased XRALDH2 activity has a posteriorizing effect on the central nervous system of Xenopus embryos.
Mechanisms of development - 1 Mar 2001
Chen Y, Pollet N, Niehrs C, Pieler T
Abstract excerpt
Retinoic acid (RA) metabolizing enzymes play important roles in RA signaling during vertebrate embryogenesis. We have previously reported on a RA degrading enzyme, XCYP26, which appears to be critical for the anteroposterior patterning of the central nervous system (EMBO J. 17 (1998) 7361). Here, we report on the sequence, expression and function of its counterpart, XRALDH2, a RA generating enzyme in Xenopus....
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