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Article

The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis.

The Journal of biological chemistry - 23 May 2014

Adams Mark K, Belyaeva Olga V, Wu Lizhi, Kedishvili Natalia Y

Abstract excerpt

The retinoic acid-inducible dehydrogenase reductase 3 (DHRS3) is thought to function as a retinaldehyde reductase that controls the levels of all-trans-retinaldehyde, the immediate precursor for bioactive all-trans-retinoic acid. However, the weak catalytic activity of DHRS3 and the lack of changes in retinaldehyde conversion to retinol and retinoic acid in the cells overexpressing DHRS3 undermine its role as a...

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Identifiers

PMID: 24733397
DOI: 10.1074/jbc.M114.552257
PMCID: PMC4031538

Genes

DHRS3
RDH10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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