Article
Gating currents in Shaker K+ channels. Implications for activation and inactivation models.
Biophysical journal - 1 Apr 1992
Perozo E, Papazian D M, Stefani E, Bezanilla F
Abstract excerpt
We have studied ionic and gating currents in mutant and wild-type Shaker K+ channels to investigate the mechanisms of channel activation and the relationship between the voltage sensor of the channel and its inactivation particle. The turn on of the gating current shows a rising phase, indicating that the hypothetical identical activation subunits are not independent. Hyperpolarizing prepulses indicate that most...
Topics
- Animals
- Biophysical Phenomena
- Biophysics
- Drosophila melanogaster
- Electrochemistry
- Female
- Ion Channel Gating
- Kinetics
- Models, Biological
- Mutation
- Oocytes
- Potassium Channels