Article
Regulation of Shaker K+ channel inactivation gating by the cAMP-dependent protein kinase.
Neuron - 1 May 1994
Drain P, Dubin A E, Aldrich R W
Abstract excerpt
In response to depolarization of the membrane potential, Shaker K+ channels undergo a series of voltage-dependent conformational changes, from resting to open conformations followed by a rapid transition into a long-lived closed conformation, the N-type inactivated state. Application of phosphatases to the cytoplasmic side of Shaker channels in excised inside-out patches slows N-type inactivation gating....
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