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Article

Antidepressant Outcomes Predicted by Genetic Variation in Corticotropin-Releasing Hormone Binding Protein.

The American journal of psychiatry - 1 Mar 2018

O'Connell Chloe P, Goldstein-Piekarski Andrea N, Nemeroff Charles B, Schatzberg Alan F, Debattista Charles, Carrillo-Roa Tania, Binder Elisabeth B, Dunlop Boadie W, Craighead W Edward, Mayberg Helen S, Williams Leanne M

Abstract excerpt

OBJECTIVE: Genetic variation within the hypothalamic-pituitary-adrenal (HPA) axis has been linked to risk for depression and antidepressant response. However, these associations have yet to produce clinical gains that inform treatment decisions. The authors investigated whether variation within HPA axis genes predicts antidepressant outcomes within two large clinical trials. METHOD: The test sample comprised 636...

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Identifiers

PMID: 29241359
DOI: 10.1176/appi.ajp.2017.17020172
PMCID: PMC5832545

Genes

CRHBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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