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Article

Filamin B regulates chondrocyte proliferation and differentiation through Cdk1 signaling.

PloS one - 1 Jan 2014

Hu Jianjun, Lu Jie, Lian Gewei, Zhang Jingping, Hecht Jonathan L, Sheen Volney L

Abstract excerpt

Humans who harbor loss of function mutations in the actin-associated filamin B (FLNB) gene develop spondylocarpotarsal syndrome (SCT), a disorder characterized by dwarfism (delayed bone formation) and premature fusion of the vertebral, carpal and tarsal bones (premature differentiation). To better understand the cellular and molecular mechanisms governing these seemingly divergent processes, we generated and...

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Source

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Identifiers

PMID: 24551245
DOI: 10.1371/journal.pone.0089352
PMCID: PMC3925234

Genes

FLNB
SCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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