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Article

Rac1 expression by fibroblasts is required for tissue repair in vivo.

The American journal of pathology - 1 May 2009

Liu Shangxi, Kapoor Mohit, Leask Andrew

Abstract excerpt

Tissue repair requires that fibroblasts migrate into the wound to produce and remodel extracellular matrix, a process that requires adhesion. Failure to suppress the tissue repair program results in fibrotic disorders that are characterized by excessive adhesive signaling. The role of specific components of adhesive signaling in fibrogenic responses is unclear, but may involve small GTPases such as Rac1. To...

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Identifiers

PMID: 19349358
DOI: 10.2353/ajpath.2009.080779
PMCID: PMC2671273

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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