Article
PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2013
MacKenzie Kirsty F, Clark Kristopher, Naqvi Shaista, McGuire Victoria A, Nöehren Gesa, Kristariyanto Yosua, van den Bosch Mirjam, Mudaliar Manikhandan, McCarthy Pierre C, Pattison Michael J, Pedrioli Patrick G A, Barton Geoff J, Toth Rachel, Prescott Alan, Arthur J Simon C
Abstract excerpt
The polarization of macrophages into a regulatory-like phenotype and the production of IL-10 plays an important role in the resolution of inflammation. We show in this study that PGE(2), in combination with LPS, is able to promote an anti-inflammatory phenotype in macrophages characterized by high expression of IL-10 and the regulatory markers SPHK1 and LIGHT via a protein kinase A-dependent pathway. Both TLR...
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