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HDAC6 promotes PMA-induced megakaryocyte differentiation of K562 cells by regulating ROS levels <i>via</i> NOX4 and repressing Glycophorin A

2019-03-14

Abstract excerpt

The human erythroleukemia (K562) cells are considered as bipotent megakaryocyte-erythroid progenitor cells and the differentiation of these cells to megakaryocytes (MK) in the presence of phorbol 12-myristate 13-acetate (PMA) mimics in vivo differentiation of MEP (megakaryocyte-erythroid progenitor) cells in the bone marrow. Histone deacetylases (HDACs) are involved in gene suppression and their roles during the...

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Literature Corpus work
aa0d6467-b3ae-5ae5-84e0-a29652ee4bf3
DOI
10.1101/578096
Open publication

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