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Article

Phorbol ester treatment of K562 cells regulates the transcriptional activity of AML1c through phosphorylation.

The Journal of biological chemistry - 17 Dec 2004

Zhang Youhong, Biggs Joseph R, Kraft Andrew S

Abstract excerpt

We find that phorbol ester (PE) treatment of K562 cells greatly stimulates promoters (T cell receptor beta, myeloperoxidase, macrophage colony-stimulating factor receptor, and granulocyte macrophage colony-stimulating factor receptor) containing AML1 transcription factor binding sites. This stimulation of AML1c transcriptional activity is mediated by direct phosphorylation of the AML1c molecule on multiple...

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PMID: 15475366
DOI: 10.1074/jbc.M405502200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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