Article
Constitutively active MAP kinase kinase (MEK1) stimulates SAP kinase and c-Jun transcriptional activity in U937 human leukemic cells.
Oncogene - 7 Dec 1995
Franklin C C, Kraft A S
Abstract excerpt
Treatment of U937 human leukemic cells with the phorbol ester PMA, activates both mitogen-activated protein kinase (MAPK) and stress-activated protein kinase (SAPK), stimulates c-Jun phosphorylation and transcriptional activity, and induces a macrophage-like differentiation of U937 cells. The inv...
Topics
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Cycle Proteins
- Cell Differentiation
- Cell Division
- Cell Line
- Dual Specificity Phosphatase 1
- Enzyme Activation
- Enzyme Induction
- Haplorhini
- Humans
- Immediate-Early Proteins
- JNK Mitogen-Activated Protein Kinases
- Leukemia
- Mitogen-Activated Protein Kinase Kinases
- Mitogen-Activated Protein Kinases
- Mutation
- Phosphoprotein Phosphatases