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Article

Rare variants in MYD88, IRAK4 and IKBKG and susceptibility to invasive pneumococcal disease: a population-based case-control study.

PloS one - 1 Jan 2015

Ellis Magda K, Elliott Katherine S, Rautanen Anna, Crook Derrick W, Hill Adrian V S, Chapman Stephen J

Abstract excerpt

Although rare variants within the Toll-like receptor signalling pathway genes have been found to underlie human primary immunodeficiencies associated with selective predisposition to invasive pneumococcal disease (IPD), the contribution of variants in these genes to IPD susceptibility at the population level remains unknown. Complete re-sequencing of IRAK4, MYD88 and IKBKG genes was undertaken in 164 IPD cases...

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Share to Case-Control Studies
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to I-kappa B Kinase

Share to Interleukin-1 Receptor-Associated Kinases

Share to Mutation, Missense

Share to Myeloid Differentiation Factor 88

Share to Pneumococcal Infections

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Source

Open in PubMed Open full text

Identifiers

PMID: 25886387
DOI: 10.1371/journal.pone.0123532
PMCID: PMC4401548

Genes

IRAK4
MYD88

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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