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Article

A hypomorphic lsd1 allele results in heart development defects in mice.

PloS one - 1 Jan 2013

Nicholson Thomas B, Singh Anup K, Su Hui, Hevi Sarah, Wang Jing, Bajko Jeff, Li Mei, Valdez Reginald, Goetschkes Margaret, Capodieci Paola, Loureiro Joseph, Cheng Xiaodong, Li En, Kinzel Bernd, Labow Mark, Chen Taiping

Abstract excerpt

Lysine-specific demethylase 1 (Lsd1/Aof2/Kdm1a), the first enzyme with specific lysine demethylase activity to be described, demethylates histone and non-histone proteins and is essential for mouse embryogenesis. Lsd1 interacts with numerous proteins through several different domains, most notably the tower domain, an extended helical structure that protrudes from the core of the protein. While there is evidence...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23637775
DOI: 10.1371/journal.pone.0060913
PMCID: PMC3634827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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