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Article

A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression.

Pharmacogenetics and genomics - 1 Mar 2007

Wilkie Murray J V, Smith Daniel, Reid Ian C, Day Richard K, Matthews Keith, Wolf Charles Roland, Blackwood Douglas, Smith Gillian

Abstract excerpt

OBJECTIVE: Recent evidence suggests that signalling cascades located downstream of monoamine receptors are altered following antidepressant treatment. Our objective was to investigate whether genetic polymorphisms in genes involved in these signalling cascades influenced antidepressant efficacy. METHODS: Polymorphisms in the G-protein beta subunit GNB3, the cAMP response element binding protein 1 gene (CREB1),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17460549
DOI: 10.1097/FPC.0b013e32801a3be6

Genes

BDNF
CREBBP
GNB3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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