Article
BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depression.
Pharmacogenetics and genomics - 1 Jun 2013
Murphy Greer M, Sarginson Jane E, Ryan Heather S, O'Hara Ruth, Schatzberg Alan F, Lazzeroni Laura C
Abstract excerpt
AIM: Brain-derived neurotrophic factor (BDNF) is associated with antidepressant response on the cellular level, in animal models, and in clinical studies. A common variant in the BDNF gene results in a substitution of a methionine (Met) for a valine at the amino acid position 66. Previous studies reported that the Met variant results in enhanced response to antidepressant medications. These findings may be at...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.