Article
The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets.
Nature immunology - 6 Nov 2011
Yang Cliff Y, Best J Adam, Knell Jamie, Yang Edward, Sheridan Alison D, Jesionek Adam K, Li Haiyan S, Rivera Richard R, Lind Kristin Camfield, D'Cruz Louise M, Watowich Stephanie S, Murre Cornelis, Goldrath Ananda W
Abstract excerpt
During infection, naive CD8(+) T cells differentiate into effector cells, which are armed to eliminate pathogens, and memory cells, which are poised to protect against reinfection. The transcriptional program that regulates terminal differentiation into short-lived effector-memory versus long-lived memory cells is not clearly defined. Through the use of mice expressing reporters for the DNA-binding inhibitors Id2...
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