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IRF2 is required for development and functional maturation of human NK cells

5 Dec 2022

Abstract excerpt

Natural killer (NK) cells are cytotoxic and cytokine-producing lymphocytes that play an important role in the first line of defense against malignant or virus-infected cells. A better understanding of the transcriptional regulation of human NK cell differentiation is crucial to improve the efficacy of NK cell-mediated immunotherapy for cancer treatment. Here, we studied the role of the transcription factor...

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Identifiers

PMID: 36544762
DOI: 10.3389/fimmu.2022.1038821

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