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Article

Localization of an NH(2)-terminal disease-causing mutation hot spot to the "clamp" region in the three-dimensional structure of the cardiac ryanodine receptor.

The Journal of biological chemistry - 15 Jun 2007

Wang Ruiwu, Chen Wenqian, Cai Shitian, Zhang Jing, Bolstad Jeff, Wagenknecht Terence, Liu Zheng, Chen S R Wayne

Abstract excerpt

A region between residues 414 and 466 in the cardiac ryanodine receptor (RyR2) harbors more than half of the known NH(2)-terminal mutations associated with cardiac arrhythmias and sudden death. To gain insight into the structural basis of this NH(2)-terminal mutation hot spot, we have determined its location in the three-dimensional structure of RyR2. Green fluorescent protein (GFP), used as a structural marker,...

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Identifiers

PMID: 17452324
DOI: 10.1074/jbc.M700660200
PMCID: PMC2800043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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