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Article

Structural insights into the human RyR2 N-terminal region involved in cardiac arrhythmias.

Acta crystallographica. Section D, Biological crystallography - 1 Nov 2014

Borko Lubomír, Bauerová-Hlinková Vladena, Hostinová Eva, Gašperík Juraj, Beck Konrad, Lai F Anthony, Zahradníková Alexandra, Sevčík Jozef

Abstract excerpt

Human ryanodine receptor 2 (hRyR2) mediates calcium release from the sarcoplasmic reticulum, enabling cardiomyocyte contraction. The N-terminal region of hRyR2 (amino acids 1-606) is the target of >30 arrhythmogenic mutations and contains a binding site for phosphoprotein phosphatase 1. Here, the solution and crystal structures determined under near-physiological conditions, as well as a homology model of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25372681
DOI: 10.1107/S1399004714020343
PMCID: PMC4220973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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