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Article

Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptor.

Journal of cell science - 15 May 2010

Liu Zheng, Wang Ruiwu, Tian Xixi, Zhong Xiaowei, Gangopadhyay Jaya, Cole Richard, Ikemoto Noriaki, Chen S R Wayne, Wagenknecht Terence

Abstract excerpt

Naturally occurring mutations in the cardiac ryanodine receptor (RyR2) have been linked to certain types of cardiac arrhythmias and sudden death. Two mutation hotspots that lie in the N-terminal and central regions of RyR2 are predicted to interact with one another and to form an important channel regulator switch. To monitor the conformational dynamics involving these regions, we generated a fluorescence...

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Identifiers

PMID: 20427316
DOI: 10.1242/jcs.064071
PMCID: PMC2864716

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CFP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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