Article
Minotaur is critical for primary piRNA biogenesis.
RNA (New York, N.Y.) - 1 Aug 2013
Vagin Vasily V, Yu Yang, Jankowska Anna, Luo Yicheng, Wasik Kaja A, Malone Colin D, Harrison Emily, Rosebrock Adam, Wakimoto Barbara T, Fagegaltier Delphine, Muerdter Felix, Hannon Gregory J
Abstract excerpt
Piwi proteins and their associated small RNAs are essential for fertility in animals. In part, this is due to their roles in guarding germ cell genomes against the activity of mobile genetic elements. piRNA populations direct Piwi proteins to silence transposon targets and, as such, form a molecular code that discriminates transposons from endogenous genes. Information ultimately carried by piRNAs is encoded...
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