Article
A common polymorphism in the interleukin-6 gene promoter is associated with overweight.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Oct 2004
Wernstedt I, Eriksson A-L, Berndtsson A, Hoffstedt J, Skrtic S, Hedner T, Hultén L M, Wiklund O, Ohlsson C, Jansson J-O
Abstract excerpt
OBJECTIVE: Human body fat mass is to a large extent genetically determined, but little is known about the susceptibility genes for common obesity. Interleukin-6 (IL-6) suppresses body fat mass in rodents, and IL-6 treatment increases energy expenditure in both rodents and humans. The -174 G/C single-nucleotide polymorphism (SNP) in the IL-6 gene promoter is common in many populations, and -174 C-containing...
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