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Article

Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals.

The Journal of clinical endocrinology and metabolism - 1 Sept 2007

Qi Lu, Zhang Cuilin, van Dam Rob M, Hu Frank B

Abstract excerpt

CONTEXT: IL-6 (IL6) is an immune-modulating cytokine associated with obesity in humans. OBJECTIVE: Our objective was to assess the associations between the genetic variability of IL6 gene and adiposity and long-term changes. DESIGN AND SUBJECTS: We determined the linkage disequilibrium-tagging single-nucleotide polymorphisms of IL6 gene in 2255 healthy women and 980 healthy men from two prospective cohorts. We...

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Identifiers

PMID: 17623760
DOI: 10.1210/jc.2007-0877

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