Article
A common functional variant in the interleukin-6 gene is associated with increased body mass index in subjects with type 2 diabetes mellitus.
Molecular genetics and metabolism - 1 Jun 2004
Stephens Jeffrey W, Hurel Steven J, Cooper Jacqueline A, Acharya Jayshree, Miller George J, Humphries Steve E
Abstract excerpt
Circulating levels of interleukin-6 (IL-6) are raised in insulin resistant states such as obesity, impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM). Growing evidence suggests that IL-6 is not only produced by fat cells but is also capable of inducing insulin resistance in these cells. The expected result of this in vivo, would be to increase adipose mass and subsequently body mass index...
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