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Article

A range of simple summary genome-wide statistics for detecting genetic linkage using high density marker data.

Genetic epidemiology - 1 Sept 2007

Saunders Ian W, Hannan Garry N, Brohede Jesper, Giles Graham G, Jenkins Mark A, Hopper John L, Southey Melissa C

Abstract excerpt

A simple approach to design and analysis of genome-wide linkage scans is described, based on an approximation to the joint distribution of likelihood ratio statistics at a large number of single nucleotide polymorphism (SNP) loci. The approximation is readily calculated and makes it feasible to study the test properties of a range of summary statistics for the entire sequence of point-wise test values. Both the...

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Identifiers

PMID: 17443708
DOI: 10.1002/gepi.20229

Genes

MLH1
MSH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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