Article
Data acquisition for meta-analysis of genome-wide linkage studies using the genome search meta-analysis method.
Human heredity - 1 Jan 2007
Forabosco Paola, Ng Mandy Y M, Bouzigon Emmanuelle, Fisher Sheila A, Levinson Douglas F, Lewis Cathryn M
Abstract excerpt
BACKGROUND: The Genome Search Meta-Analysis (GSMA) method enables researchers to pool results across genome-wide linkage studies, to increase the power to detect linkage. RESULTS from individual studies must be extracted, with the maximum evidence for linkage placed into bins, usually of 30 cM width, and ranked within the study. Ranks are then summed across studies, with high summed ranks potentially showing...
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