Article
IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-1beta genes.
European journal of immunology - 1 Aug 1998
Hurme M, Santtila S
Abstract excerpt
The genes in the IL-1 complex code for three proteins, IL-1alpha, IL-1beta and the IL-1 receptor antagonist (IL-1 Ra). The severity of a given infection is influenced by the balance between the levels of IL-1beta, the major extracellular agonist, and that of IL-1 Ra. In healthy individuals, IL-1...
Topics
- Adolescent
- Adult
- Alleles
- Base Sequence
- Blood Donors
- DNA Primers
- Finland
- Gene Expression Regulation
- Gene Frequency
- Genotype
- Humans
- Interleukin 1 Receptor Antagonist Protein
- Interleukin-1
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Sialoglycoproteins