Article
Epistatic effect of cholesteryl ester transfer protein and hepatic lipase on serum high-density lipoprotein cholesterol levels.
The Journal of clinical endocrinology and metabolism - 1 Jul 2007
Isaacs Aaron, Aulchenko Yurii S, Hofman Albert, Sijbrands Eric J G, Sayed-Tabatabaei Fakhredin A, Klungel Olaf H, Maitland-van der Zee Anke-Hilse, Stricker Bruno H Ch, Oostra Ben A, Witteman Jacqueline C M, van Duijn Cornelia M
Abstract excerpt
OBJECTIVES: Polymorphisms in the hepatic lipase (LIPC -514C > T) and cholesteryl ester transfer protein (CETP I405V) genes affect high-density lipoprotein cholesterol (HDL-c) levels, but their relationship with cardiovascular disease and their combined effect is unclear. The objectives of the current study were to characterize the effect of the hepatic lipase variant, and its interaction with the CETP variant, in...
Topics
- Aged
- Atherosclerosis
- Cholesterol Ester Transfer Proteins
- Epistasis, Genetic
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Lipase
- Lipoproteins, HDL
- Male
- Myocardial Infarction