Article
An increased coronary risk is paradoxically associated with common cholesteryl ester transfer protein gene variations that relate to higher high-density lipoprotein cholesterol: a population-based study.
The Journal of clinical endocrinology and metabolism - 1 Sept 2006
Borggreve Susanna E, Hillege Hans L, Wolffenbuttel Bruce H R, de Jong Paul E, Zuurman Mike W, van der Steege Gerrit, van Tol Arie, Dullaart Robin P F
Abstract excerpt
BACKGROUND: Several cholesteryl ester transfer protein (CETP) polymorphisms affect high-density lipoprotein (HDL) cholesterol, but the impact of CETP gene variants on incident coronary disease in the general population is uncertain after correction for their effect on HDL cholesterol. DESIGN: We determined relationships between the CETP -629C-->A promoter (n = 8141), the TaqIB (n = 8289), and the I405V (n = 8265)...
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