Article
Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study.
Circulation - 29 Oct 2002
Ordovas Jose M, Corella Dolores, Demissie Serkalem, Cupples L Adrienne, Couture Patrick, Coltell Oscar, Wilson Peter W F, Schaefer Ernst J, Tucker Katherine L
Abstract excerpt
BACKGROUND: Gene-nutrient interactions affecting high-density lipoprotein cholesterol (HDL-C) concentrations may contribute to the interindividual variability of the cardiovascular disease risk associated with dietary fat intake. Hepatic lipase (HL) is a key determinant of HDL metabolism. Four polymorphisms in linkage disequilibrium have been identified in the HL gene (LIPC), defining what is known as the -514T...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.