Article
Hepatic lipase mutations,elevated high-density lipoprotein cholesterol, and increased risk of ischemic heart disease: the Copenhagen City Heart Study.
Journal of the American College of Cardiology - 4 Jun 2003
Andersen Rolf V, Wittrup Hans H, Tybjaerg-Hansen Anne, Steffensen Rolf, Schnohr Peter, Nordestgaard Børge G
Abstract excerpt
OBJECTIVES: We investigated associations between single nucleotide polymorphisms (SNPs) in the hepatic lipase promoter, levels of high-density lipoprotein (HDL), and risk of ischemic heart disease (IHD). Our primary hypothesis was that these SNPs associate with IHD after adjustment for HDL levels. BACKGROUND: Hepatic lipase influences HDL metabolism, and may thus affect reverse cholesterol transport and...
Topics
- Adult
- Aged
- Aged, 80 and over
- Apolipoprotein A-I
- Apolipoproteins E
- Case-Control Studies
- Cholesterol, HDL
- Cholesterol, LDL
- Cross-Sectional Studies
- Female