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Article

Neddylation-induced conformational control regulates cullin RING ligase activity in vivo.

Journal of molecular biology - 3 Jun 2011

Boh Boon Kim, Smith Peter G, Hagen Thilo

Abstract excerpt

Cullin RING ligases (CRLs) constitute the largest family of ubiquitin ligases with diverse cellular functions. Conjugation of the ubiquitin-like molecule Nedd8 to a conserved lysine residue on the cullin scaffold is essential for the activity of CRLs. Using structural studies and in vitro assays, it has been demonstrated that neddylation stimulates CRL activity through conformational rearrangement of the cullin...

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PMID: 21463634
DOI: 10.1016/j.jmb.2011.03.023

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