Article
CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis.
Human genetics - 1 Apr 2005
Lee Young Ho, Harley John B, Nath Swapan K
Abstract excerpt
Several reports demonstrate association between variants of the cytotoxic T lymphocyte antigen-4 (CTLA-4) and autoimmune diseases. CTLA-4 may generate autoimmunity by immune dysregulation, making CTLA-4 an attractive candidate gene for systemic lupus erythematosus (SLE) susceptibility. Previous CTLA-4 association studies with SLE, however, have produced inconsistent results. We have performed a meta-analysis to...
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