Article
[Polymorphism A/G in position +49 of CTLA4 exon 1 in multiple sclerosis in Russians].
Molekuliarnaia biologiia - 1 Jan 2000
Andreevskiĭ T V, Sudomoina M A, Gusev E I, Boĭko A N, Alekseenkov A D, Favorova O O
Abstract excerpt
The association of multiple sclerosis (MS) with alleles A and G of the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene, a candidate gene for autoimmune disorders, was studied. The allele polymorphism results from single nucleotide substitution (A/G) in position +49 of exon 1 and leads to substitution Thr-->Ala in the leader peptide. The case-control study involved two groups of ethnic Russians: 168 MS patients and...
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