Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reactive site-dependent phenotypic alterations in plasminogen activator inhibitor-1 transgenic mice.

Journal of thrombosis and haemostasis : JTH - 1 Jul 2007

Eren M, Gleaves L A, Atkinson J B, King L E, Declerck P J, Vaughan D E

Abstract excerpt

BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1) is the major physiological inhibitor of plasminogen activators (PAs) and plays a role in the regulation of a number of physiological processes including the degradation of extracellular matrix proteins, cell proliferation and migration, and intracellular signaling. AIM: To characterize the effects of durable expression of a stable form of human PAI-1 and to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunohistochemistry
Share to Mice, Transgenic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutagenesis, Site-Directed

Share to Plasminogen Activator Inhibitor 1

Share to Protein Structure, Tertiary

Share to Recombinant Proteins

Share to Tissue Distribution

Source

Identifiers

PMID: 17439629
DOI: 10.1111/j.1538-7836.2007.02587.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reactive site-dependent phenotypic alterations in plasminogen activator inhibitor-1 transgenic mice.PMID 17439629Read ↗

Transgenic overexpression of a stable Plasminogen Activator Inhibitor-1 variant.Semantic proximity Read ↗

Subtle structural differences between human and mouse PAI-1 reveal the basis for biochemical differences.Semantic proximity Read ↗

Life-threatening hemorrhage and prolonged wound healing are remarkable phenotypes manifested by complete plasminogen activator inhibitor-1 deficiency in humans.Semantic proximity Read ↗

Historical analysis of PAI-1 from its discovery to its potential role in cell motility and diseaseSemantic proximity Read ↗

Genetic interactions between the coagulation and fibrinolytic systems.Semantic proximity Read ↗

Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator.Semantic proximity Read ↗

Gene targeting of components of the fibrinolytic system.Semantic proximity Read ↗

Structure-function relationships of plasminogen activator inhibitor-1 and its potential as a therapeutic agent.Semantic proximity Read ↗

Three Decades of Research on Plasminogen Activator Inhibitor-1: A Multifaceted SerpinSemantic proximity Read ↗

PAI-1 is a common driver of aging and diverse diseasesSemantic proximity Read ↗

New insights into the biology of tissue factor pathway inhibitor.Semantic proximity Read ↗

Good or bad: Paradox of plasminogen activator inhibitor 1 (PAI-1) in digestive system tumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.