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Article

Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo.

Development (Cambridge, England) - 1 Feb 2011

Fossat Nicolas, Jones Vanessa, Khoo Poh-Lynn, Bogani Debora, Hardy Andrea, Steiner Kirsten, Mukhopadhyay Mahua, Westphal Heiner, Nolan Patrick M, Arkell Ruth, Tam Patrick P L

Abstract excerpt

In mouse embryos, loss of Dickkopf-1 (DKK1) activity is associated with an ectopic activation of WNT signalling responses in the precursors of the craniofacial structures and leads to a complete truncation of the head at early organogenesis. Here, we show that ENU-induced mutations of genes codin...

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Source

Identifiers

PMID: 21228006
DOI: 10.1242/dev.052803

Genes

DKK1
LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21228006-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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