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Article

SynGAP regulates spine formation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Oct 2004

Vazquez Luis E, Chen Hong-Jung, Sokolova Irina, Knuesel Irene, Kennedy Mary B

Abstract excerpt

SynGAP is a brain-specific ras GTPase-activating protein that is an abundant component of the signaling complex associated with the NMDA-type glutamate receptor. We generated mutant mice lacking synGAP to study its physiological role. Homozygous mutant mice die in the first few days after birth; however, neurons from mutant embryos can be maintained in culture. Here, we report that spine and synapse formation are...

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Source

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Identifiers

PMID: 15470153
DOI: 10.1523/JNEUROSCI.3213-04.2004
PMCID: PMC6729942

Genes

PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SynGAP regulates spine formation.PMID 15470153Read ↗

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