Article
Nuclear export of ribosomal 60S subunits by the general mRNA export receptor Mex67-Mtr2.
Molecular cell - 13 Apr 2007
Yao Wei, Roser Daniela, Köhler Alwin, Bradatsch Bettina, Bassler Jochen, Hurt Ed
Abstract excerpt
The yeast Mex67-Mtr2 complex and its homologous metazoan counterpart TAP-p15 operate as nuclear export receptors by binding and translocating mRNA through the nuclear pore complexes. Here, we show how Mex67-Mtr2 can also function in the nuclear export of the ribosomal 60S subunit. Biochemical and genetic studies reveal a previously unrecognized interaction surface on the NTF2-like scaffold of the Mex67-Mtr2...
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