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Article

Role of Mex67-Mtr2 in the nuclear export of 40S pre-ribosomes.

PLoS genetics - 1 Jan 2012

Faza Marius B, Chang Yiming, Occhipinti Laura, Kemmler Stefan, Panse Vikram G

Abstract excerpt

Nuclear export of mRNAs and pre-ribosomal subunits (pre40S and pre60S) is fundamental to all eukaryotes. While genetic approaches in budding yeast have identified bona fide export factors for mRNAs and pre60S subunits, little is known regarding nuclear export of pre40S subunits. The yeast heterodimeric transport receptor Mex67-Mtr2 (TAP-p15 in humans) binds mRNAs and pre60S subunits in the nucleus and facilitates...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22956913
DOI: 10.1371/journal.pgen.1002915
PMCID: PMC3431309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of Mex67-Mtr2 in the nuclear export of 40S pre-ribosomes.PMID 22956913Read ↗

Nuclear export of ribosomal 60S subunits by the general mRNA export receptor Mex67-Mtr2.Semantic proximity Read ↗

Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores.Semantic proximity Read ↗

Non-FG mediated transport of the large pre-ribosomal subunit through the nuclear pore complex by the mRNA export factor Gle2.Semantic proximity Read ↗

The mRNA export factor Npl3 mediates the nuclear export of large ribosomal subunits.Semantic proximity Read ↗

Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores.Semantic proximity Read ↗

Utp8p is a nucleolar tRNA-binding protein that forms a complex with components of the nuclear tRNA export machinery in Saccharomyces cerevisiae.Semantic proximity Read ↗

Conserved nuclear export sequences in Schizosaccharomyces pombe Mex67 and human TAP function in mRNA export by direct nuclear pore interactions.Semantic proximity Read ↗

Mutations in tap uncouple RNA export activity from translocation through the nuclear pore complex.Semantic proximity Read ↗

Nuclear mRNA export requires specific FG nucleoporins for translocation through the nuclear pore complex.Semantic proximity Read ↗

A non-canonical mechanism for Crm1-export cargo complex assembly.Semantic proximity Read ↗

Nuclear export of the pre-60S ribosomal subunit through single nuclear pores observed in real timeSemantic proximity Read ↗

Nuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p.Semantic proximity Read ↗

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