Article
Concerted removal of the Erb1-Ytm1 complex in ribosome biogenesis relies on an elaborate interface.
Nucleic acids research - 29 Jan 2016
Thoms Matthias, Ahmed Yasar Luqman, Maddi Karthik, Hurt Ed, Sinning Irmgard
Abstract excerpt
The complicated process of eukaryotic ribosome biogenesis involves about 200 assembly factors that transiently associate with the nascent pre-ribosome in a spatiotemporally ordered way. During the early steps of 60S subunit formation, several proteins, collectively called A3 cluster factors, participate in the removal of the internal transcribed spacer 1 (ITS1) from 27SA3 pre-rRNA. Among these factors is the...
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