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Article

Conserved nuclear export sequences in Schizosaccharomyces pombe Mex67 and human TAP function in mRNA export by direct nuclear pore interactions.

The Journal of biological chemistry - 23 Apr 2004

Thakurta Anjan G, Gopal Ganesh, Yoon Jin Ho, Saha Tapas, Dhar Ravi

Abstract excerpt

Mex67, the homolog of human TAP, is not an essential mRNA export factor in Schizosaccharomyces pombe. Here we show that S. pombe encodes a homolog of the TAP cofactor that we have also named p15, whose function in mRNA export is not essential. We have identified and characterized two distinct nuclear export activities, nuclear export signal (NES) I and NES II, within the region of amino acids 434-509 of Mex67....

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Identifiers

PMID: 14963046
DOI: 10.1074/jbc.M309731200

Genes

NES

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conserved nuclear export sequences in Schizosaccharomyces pombe Mex67 and human TAP function in mRNA export by direct nuclear pore interactions.PMID 14963046Read ↗

Mex67p of Schizosaccharomyces pombe interacts with Rae1p in mediating mRNA export.Semantic proximity Read ↗

Role of Mex67-Mtr2 in the nuclear export of 40S pre-ribosomes.Semantic proximity Read ↗

Schizosaccharomyces pombe nup97, which Genetically Interacts with mex67, is essential for growth and involved in mRNA export.Semantic proximity Read ↗

Npp106p, a Schizosaccharomyces pombe nucleoporin similar to Saccharomyces cerevisiae Nic96p, functionally interacts with Rae1p in mRNA export.Semantic proximity Read ↗

NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells.Semantic proximity Read ↗

Mutations in tap uncouple RNA export activity from translocation through the nuclear pore complex.Semantic proximity Read ↗

Nuclear export of ribosomal 60S subunits by the general mRNA export receptor Mex67-Mtr2.Semantic proximity Read ↗

Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores.Semantic proximity Read ↗

Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores.Semantic proximity Read ↗

The N-terminal domain of Nup159 forms a beta-propeller that functions in mRNA export by tethering the helicase Dbp5 to the nuclear pore.Semantic proximity Read ↗

An elevated level of the mRNA exporter Mex67-Mtr2 in nuclear mRNPs impairs nuclear mRNA exportSemantic proximity Read ↗

The DEAD-box protein Dbp5p is required to dissociate Mex67p from exported mRNPs at the nuclear rim.Semantic proximity Read ↗

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