Article
Comprehensive SNP array study of frequently used neuroblastoma cell lines; copy neutral loss of heterozygosity is common in the cell lines but uncommon in primary tumors.
BMC genomics - 7 Sept 2011
Kryh Hanna, Carén Helena, Erichsen Jennie, Sjöberg Rose-Marie, Abrahamsson Jonas, Kogner Per, Martinsson Tommy
Abstract excerpt
BACKGROUND: Copy neutral loss of heterozygosity (CN-LOH) refers to a special case of LOH occurring without any resulting loss in copy number. These alterations is sometimes seen in tumors as a way to inactivate a tumor suppressor gene and have been found to be important in several types of cancer. RESULTS: We have used high density single nucleotide polymorphism arrays in order to investigate the frequency and...
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