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Article

Akt mediates self-renewal division of mouse spermatogonial stem cells

12 Apr 2007

Abstract excerpt

Spermatogonial stem cells have unique properties to self-renew and support spermatogenesis throughout their lifespan. Although glial cell line-derived neurotrophic factor (GDNF) has recently been identified as a self-renewal factor for spermatogonial stem cells, the molecular mechanism of spermatogonial stem cell self-renewal remains unclear. In the present study, we assessed the role of the phosphoinositide-3...

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PMID: 17428826
DOI: 10.1242/dev.003004

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