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Article

MEK/ERK signaling directly and indirectly contributes to the cyclical self-renewal of spermatogonial stem cells

29 Jul 2013

Abstract excerpt

Coordination of stem cell fate is regulated by extrinsic niche signals and stem cell intrinsic factors. In mammalian testes, spermatogonial stem cells maintain constant production of abundant spermatozoa by alternating between self-renewal and differentiation at regular intervals according to a periodical program known as the seminiferous epithelial cycle. Although retinoic acid (RA) signaling has been suggested...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 23897718
DOI: 10.1002/stem.1486

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