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Article

Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells.

Oncogene - 4 May 2006

Watanabe S, Umehara H, Murayama K, Okabe M, Kimura T, Nakano T

Abstract excerpt

Embryonic stem (ES) cells can self-renew indefinitely without losing their differentiation ability to any cell types. Phosphoinositide-3 kinase (PI3K)/Akt signaling plays a pivotal role in various stem cell systems, including the formation of embryonic germ (EG) cells from primordial germ cells and self-renewal of neural stem cells. Here, we show that myristoylated, active form of Akt (myr-Akt) maintained the...

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PMID: 16407845
DOI: 10.1038/sj.onc.1209307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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