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SPRY4-dependent ERK negative feedback demarcates functional adult stem cells in the male mouse germline

8 Aug 2023

Abstract excerpt

Niche-derived growth factors support self-renewal of mouse spermatogonial stem and progenitor cells through ERK MAPK signaling and other pathways. At the same time, dysregulated growth factor-dependent signaling has been associated with loss of stem cell activity and aberrant differentiation. We hypothesized that growth factor signaling through the ERK MAPK pathway in spermatogonial stem cells is tightly...

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PMID: 37552049
DOI: 10.1093/biolre/ioad089

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