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Article

The In Vivo Response of Stem and Other Undifferentiated Spermatogonia to the Reversible Inhibition of Glial Cell Line-Derived Neurotrophic Factor Signaling in the Adult

9 Jan 2012

Abstract excerpt

Maintaining adequate numbers of spermatogonial stem cells is required for the production of the millions of sperm required for male fertility. To date, however, the mechanisms that regulate the size of this pool in the adult are poorly defined. Glial cell line-derived neurotrophic factor (GDNF) is required for establishing this pool in the prepubertal animal, but its in vivo function in the normal adult testis...

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PMID: 22232066
DOI: 10.1002/stem.1028

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Related research

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The In Vivo Response of Stem and Other Undifferentiated Spermatogonia to the Reversible Inhibition of Glial Cell Line-Derived Neurotrophic Factor Signaling in the AdultPMID 22232066Read ↗

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NANOS2 Acts Downstream of Glial Cell Line-Derived Neurotrophic Factor Signaling to Suppress Differentiation of Spermatogonial Stem CellsSemantic proximity Read ↗

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Cyclical expression of GDNF is required for spermatogonial stem cell homeostasisSemantic proximity Read ↗

Spermatogonial Stem Cell Self-Renewal and DevelopmentSemantic proximity Read ↗

The production of glial cell line-derived neurotrophic factor by human sertoli cells is substantially reduced in sertoli cell-only testesSemantic proximity Read ↗

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