Clock genes beyond the clock: CLOCK genotype biases neural correlates of moral valence decision in depressed patients.

doi:10.1111/j.1601-183X.2007.00312.x

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Article

Clock genes beyond the clock: CLOCK genotype biases neural correlates of moral valence decision in depressed patients.

Genes, brain, and behavior - 1 Feb 2008

Benedetti F, Radaelli D, Bernasconi A, Dallaspezia S, Falini A, Scotti G, Lorenzi C, Colombo C, Smeraldi E

Abstract excerpt

Gene polymorphisms in the mammalian biological clock system influence individual rhythms. A single nucleotide polymorphism (SNP) in the 3' flanking region of CLOCK (3111 T/C; rs1801260) influenced diurnal preference in healthy humans and caused sleep phase delay and insomnia in patients affected by bipolar disorder. Genes of the biological clock are expressed in many brain structures other than in the 'master...

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PMID: 17428266
DOI: 10.1111/j.1601-183X.2007.00312.x

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