Article
Clock gene variants differentiate mood disorders.
Molecular biology reports - 1 Jan 2015
Dmitrzak-Weglarz Monika Paulina, Pawlak Joanna Maria, Maciukiewicz Malgorzata, Moczko Jerzy, Wilkosc Monika, Leszczynska-Rodziewicz Anna, Zaremba Dorota, Hauser Joanna
Abstract excerpt
Genetic variations in clock-related genes were hypothesized to be involved to in the susceptibility of mood disorders MD (both unipolar (UPD) and bipolar (BPD) disorders). In our work we investigated role of gene variants form four core period proteins: CLOCK, ARNTL, TIM and PER3. The total sample comprised from 744 mood disorders inpatients (UPD = 229, BPD = 515) and 635 healthy voluntary controls. The 42 SNPs...
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