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Article

Influence of <i>CLOCK</i> gene polymorphism on circadian mood fluctuation and illness recurrence in bipolar depression

15 Sept 2003

Abstract excerpt

Recent studies showed that a polymorphism (T to C nucleotide substitution) in the 3' flanking region of the human CLOCK gene is associated with diurnal preferences of human healthy subjects, with higher "eveningness" in subjects carrying at least one copy of the C allele. We investigated the possible role of CLOCK gene polymorphism in the regulation of diurnal mood fluctuations during a major depressive episode....

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PMID: 14582141
DOI: 10.1002/ajmg.b.20038

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